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HE MANAGEMENT

Recommended by experts

Once an overt hepatic encephalopathy (HE) episode occurs, there is a high risk for more episodes. These are called recurrences.

That is why HE experts recommend ongoing management to help reduce the risk of an overt HE recurrence. After a recurrence, experts recommend adding XIFAXAN to lactulose for ongoing management.

The safety and efficacy of XIFAXAN in HE patients has not been studied for longer than 6 months in clinical trials.
If patients recover a significant amount of liver function, they may be able to discontinue HE therapy.

REVIEW THE RISKS OF OVERT HE RECURRENCE

Taking XIFAXAN daily as prescribed helps reduce the risk of overt HE recurrence in adults.

LEARN MORE ABOUT XIFAXAN

Round button with nurse icon that reads Enroll in H.E.L.P. for support Round button with nurse icon that reads Enroll in H.E.L.P. for support

*Eligibility criteria, terms and conditions apply.

It can be challenging to manage overt HE. That's why ongoing help is available for adults

living with a history of HE and their caregivers—the HE Living Program (H.E.L.P.).

INDICATIONS

XIFAXAN® (rifaximin) 550 mg tablets are indicated for the reduction in risk of overt hepatic encephalopathy (HE) recurrence in adults and for the treatment of irritable bowel syndrome with diarrhea (IBS-D) in adults.

IMPORTANT SAFETY INFORMATION

  • XIFAXAN is not for everyone. Do not take XIFAXAN if you have a known hypersensitivity to rifaximin, any of the rifamycin antimicrobial agents, or any of the components in XIFAXAN
  • If you take antibiotics, like XIFAXAN, there is a chance you could experience diarrhea caused by an overgrowth of bacteria (C. difficile). This can cause symptoms ranging in severity from mild diarrhea to life-threatening colitis. Contact your healthcare provider if your diarrhea does not improve or worsens.
  • Talk to your healthcare provider before taking XIFAXAN if you have severe hepatic (liver) impairment as this may cause increased effects of the medicine.
  • Tell your healthcare provider if you are taking drugs called P-glycoprotein inhibitors (such as cyclosporine) because using these drugs with XIFAXAN may lead to an increase in the amount of XIFAXAN absorbed by your body.
  • If you are pregnant, planning to become pregnant, or nursing, talk to your healthcare provider before taking XIFAXAN because XIFAXAN may cause harm to an unborn baby or nursing infant.
  • In clinical studies, the most common side effects of XIFAXAN were:
    • HE: peripheral edema (swelling, usually in the ankles or lower limbs), nausea (feeling sick to your stomach), dizziness, fatigue (feeling tired), and ascites (a buildup of fluid in the abdomen).
    • IBS-D: Nausea (feeling sick to your stomach) and an increase in liver enzymes.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

For product information, adverse event reports, and product complaint reports, please contact:

Salix Product Information Call Center
Phone: 1-800-321-4576
Fax: 1-510-595-8183
Email: salixmc@dlss.com

Please click here for full Prescribing Information.

HE Living Program logo

A 24/7 helpline staffed by nurses

Reminder telephone calls about prescription refills and doctor visits

Additional information about HE and XIFAXAN

Tools to help plan for what comes after a hospitalization

ENROLL NOW

See MoreImportant Safety Information
See LessImportant Safety Information

INDICATIONS

XIFAXAN® (rifaximin) 550 mg tablets are indicated for the reduction in risk of overt hepatic encephalopathy (HE) recurrence in adults and for the treatment of irritable bowel syndrome with diarrhea (IBS-D) in adults.

IMPORTANT SAFETY INFORMATION

  • XIFAXAN is not for everyone. Do not take XIFAXAN if you have a known hypersensitivity to rifaximin, any of the rifamycin antimicrobial agents, or any of the components in XIFAXAN
  • If you take antibiotics, like XIFAXAN, there is a chance you could experience diarrhea caused by an overgrowth of bacteria (C. difficile). This can cause symptoms ranging in severity from mild diarrhea to life-threatening colitis. Contact your healthcare provider if your diarrhea does not improve or worsens.
  • Talk to your healthcare provider before taking XIFAXAN if you have severe hepatic (liver) impairment as this may cause increased effects of the medicine.
  • Tell your healthcare provider if you are taking drugs called P-glycoprotein inhibitors (such as cyclosporine) because using these drugs with XIFAXAN may lead to an increase in the amount of XIFAXAN absorbed by your body.
  • If you are pregnant, planning to become pregnant, or nursing, talk to your healthcare provider before taking XIFAXAN because XIFAXAN may cause harm to an unborn baby or nursing infant.
  • In clinical studies, the most common side effects of XIFAXAN were:
    • HE: peripheral edema (swelling, usually in the ankles or lower limbs), nausea (feeling sick to your stomach), dizziness, fatigue (feeling tired), and ascites (a buildup of fluid in the abdomen).
    • IBS-D: Nausea (feeling sick to your stomach) and an increase in liver enzymes.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

For product information, adverse event reports, and product complaint reports, please contact:

Salix Product Information Call Center
Phone: 1-800-321-4576
Fax: 1-510-595-8183
Email: salixmc@dlss.com

Please click here for full Prescribing Information.