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ABOUT HE

What are the symptoms of hepatic encephalopathy (HE)?

The symptoms of HE can differ from one person to another.

Also, some people with HE develop symptoms that begin slowly and get worse over time, while others develop more severe symptoms suddenly.

The range of symptoms associated with HE include:

Stage 1
  • Forgetfulness
  • Extra nervousness or excitement
  • Breath with a musty or sweet odor
Stage 2
  • Poor judgement
  • Severe personality changes
  • Worsening of handwriting
  • Loss of small hand movement
  • Tremors or shaking of hands and arms
  • Slowed or sluggish movement
Stage 3
  • Confusion
  • Not knowing where one is or where one is going
  • Inappropriate behavior
Stage 4
  • Unconsciousness
  • Coma

If you have an underlying liver disease condition and you start to develop any of these symptoms, it is important that you talk with your healthcare provider.

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*Eligibility criteria, terms and conditions apply.

These symptoms can have a big impact on daily life, such as:

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Not being able to drive a car

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Not being able to work

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Not being able to care for oneself

When HE symptoms are more severe, the condition is called “overt” HE.

Once overt HE occurs, there is a risk of more overt HE episodes, as well as hospitalization.

CLICK HERE TO LEARN ABOUT THE RISKS OF OVERT HE

INDICATION

XIFAXAN® (rifaximin) 550 mg tablets are indicated for reduction in risk of overt hepatic encephalopathy (HE) recurrence in adults.

IMPORTANT SAFETY INFORMATION - XIFAXAN (rifaximin) 550 mg tablets in HE

  • XIFAXAN is not for everyone. Do not take XIFAXAN if you have a known hypersensitivity to rifaximin, any of the rifamycin antimicrobial agents, or any of the components in XIFAXAN.
  • If you take antibiotics, like XIFAXAN, there is a chance you could experience diarrhea caused by an overgrowth of bacteria (C. difficile). This can cause symptoms ranging in severity from mild diarrhea to life-threatening colitis. Contact your healthcare provider if your diarrhea does not improve or worsens.
  • XIFAXAN has not been studied in people with MELD scores over 25 and only 8.6% of people in the controlled study had MELD scores over 19. There is an increased chance that XIFAXAN will spread through your body if you have more severe hepatic dysfunction. Therefore, if you have severe hepatic impairment, which is a Child-Pugh score of C, you should talk to your healthcare provider before taking XIFAXAN.
  • Tell your doctor if you are taking drugs called P-glycoprotein inhibitors (such as cyclosporine) because using these drugs with XIFAXAN may lead to an increase in the amount of XIFAXAN absorbed by your body.
  • If you are pregnant, planning to become pregnant, or nursing, talk to your healthcare provider before taking XIFAXAN because it is unknown if XIFAXAN can harm an unborn baby or nursing infant.
  • In the clinical study, the most common side effects in HE associated with XIFAXAN 550 mg tablets—occurring in at least 10% of people receiving XIFAXAN—were peripheral edema (swelling, usually in the ankles or lower limbs), nausea (feeling sick to your stomach), dizziness, fatigue (feeling tired), and ascites (a buildup of fluid in the abdomen).

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

For product information, adverse event reports, and product complaint reports, please contact:

Salix Product Information Call Center
Phone: 1-800-508-0024
Fax: 1-510-595-8183
Email: valeantmc@dlss.com

Please click here for full Prescribing Information for XIFAXAN.

See MoreImportant Safety Information
See LessImportant Safety Information

INDICATION

XIFAXAN® (rifaximin) 550 mg tablets are indicated for reduction in risk of overt hepatic encephalopathy (HE) recurrence in adults.

IMPORTANT SAFETY INFORMATION - XIFAXAN (rifaximin) 550 mg tablets in HE

  • XIFAXAN is not for everyone. Do not take XIFAXAN if you have a known hypersensitivity to rifaximin, any of the rifamycin antimicrobial agents, or any of the components in XIFAXAN.
  • If you take antibiotics, like XIFAXAN, there is a chance you could experience diarrhea caused by an overgrowth of bacteria (C. difficile). This can cause symptoms ranging in severity from mild diarrhea to life-threatening colitis. Contact your healthcare provider if your diarrhea does not improve or worsens.
  • XIFAXAN has not been studied in people with MELD scores over 25 and only 8.6% of people in the controlled study had MELD scores over 19. There is an increased chance that XIFAXAN will spread through your body if you have more severe hepatic dysfunction. Therefore, if you have severe hepatic impairment, which is a Child-Pugh score of C, you should talk to your healthcare provider before taking XIFAXAN.
  • Tell your doctor if you are taking drugs called P-glycoprotein inhibitors (such as cyclosporine) because using these drugs with XIFAXAN may lead to an increase in the amount of XIFAXAN absorbed by your body.
  • If you are pregnant, planning to become pregnant, or nursing, talk to your healthcare provider before taking XIFAXAN because it is unknown if XIFAXAN can harm an unborn baby or nursing infant
  • In the clinical study, the most common side effects in HE associated with XIFAXAN 550 mg tablets—occurring in at least 10% of people receiving XIFAXAN—were peripheral edema (swelling, usually in the ankles or lower limbs), nausea (feeling sick to your stomach), dizziness, fatigue (feeling tired), and ascites (a buildup of fluid in the abdomen).

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch/ or call 1-800-FDA-1088.

For product information, adverse event reports, and product complaint reports, please contact:

Salix Product Information Call Center
Phone: 1-800-508-0024
Fax: 1-510-595-8183
Email: valeantmc@dlss.com

Please click here for full Prescribing Information for XIFAXAN.