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ABOUT HE

What is hepatic encephalopathy (HE) ?

HE is a possible consequence of liver disease.

Liver disease happens to many people for lots of different reasons. In fact,
approximately 30 million people in the United States have some form of liver disease.

Some of the common types of liver disease and their causes include:

Hepatitis A, B, and C,

which are 3 different strains of the hepatitis virus that can damage the liver.


Non-alcoholic fatty liver disease (NAFLD),

which is caused by too much fat in the liver cells. 


Alcohol-related liver disease,

which is the result of drinking too much alcohol.

All of these types of liver disease can damage and scar the liver.

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Liver disease can lead to other, more serious problems, such as cirrhosis.

Having liver disease over a long period of time may damage the liver and eventually lead to its soft, healthy tissue being replaced by hard scar tissue. This condition is called cirrhosis.

As cirrhosis becomes worse, the liver will have less and less healthy tissue. The liver is important because it filters everything that you eat and drink. It processes food into energy and nutrients that your body can use. It also gets rid of harmful substances called toxins.

Cirrhosis can cause symptoms and complications over time.

Cirrhosis may not cause any symptoms or complications at first, but over time it can lead to many. One serious complication of cirrhosis is hepatic encephalopathy, or HE.

HE may happen when a liver that has been damaged by cirrhosis cannot filter toxins out of the blood. These toxins can then build up in the brain and cause a range of different mental and physical symptoms.

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INDICATIONS

XIFAXAN® (rifaximin) 550 mg tablets are indicated for the reduction in risk of overt hepatic encephalopathy (HE) recurrence in adults and for the treatment of irritable bowel syndrome with diarrhea (IBS-D) in adults.

IMPORTANT SAFETY INFORMATION

  • XIFAXAN is not for everyone. Do not take XIFAXAN if you have a known hypersensitivity to rifaximin, any of the rifamycin antimicrobial agents, or any of the components in XIFAXAN
  • If you take antibiotics, like XIFAXAN, there is a chance you could experience diarrhea caused by an overgrowth of bacteria (C. difficile). This can cause symptoms ranging in severity from mild diarrhea to life-threatening colitis. Contact your healthcare provider if your diarrhea does not improve or worsens.
  • Talk to your healthcare provider before taking XIFAXAN if you have severe hepatic (liver) impairment as this may cause increased effects of the medicine.
  • Tell your healthcare provider if you are taking drugs called P-glycoprotein inhibitors (such as cyclosporine) because using these drugs with XIFAXAN may lead to an increase in the amount of XIFAXAN absorbed by your body.
  • If you are pregnant, planning to become pregnant, or nursing, talk to your healthcare provider before taking XIFAXAN because XIFAXAN may cause harm to an unborn baby or nursing infant.
  • In clinical studies, the most common side effects of XIFAXAN were:
    • HE: peripheral edema (swelling, usually in the ankles or lower limbs), nausea (feeling sick to your stomach), dizziness, fatigue (feeling tired), and ascites (a buildup of fluid in the abdomen).
    • IBS-D: Nausea (feeling sick to your stomach) and an increase in liver enzymes.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

For product information, adverse event reports, and product complaint reports, please contact:

Salix Product Information Call Center
Phone: 1-800-321-4576
Fax: 1-510-595-8183
Email: salixmc@dlss.com

Please click here for full Prescribing Information.

See MoreImportant Safety Information
See LessImportant Safety Information

INDICATIONS

XIFAXAN® (rifaximin) 550 mg tablets are indicated for the reduction in risk of overt hepatic encephalopathy (HE) recurrence in adults and for the treatment of irritable bowel syndrome with diarrhea (IBS-D) in adults.

IMPORTANT SAFETY INFORMATION

  • XIFAXAN is not for everyone. Do not take XIFAXAN if you have a known hypersensitivity to rifaximin, any of the rifamycin antimicrobial agents, or any of the components in XIFAXAN
  • If you take antibiotics, like XIFAXAN, there is a chance you could experience diarrhea caused by an overgrowth of bacteria (C. difficile). This can cause symptoms ranging in severity from mild diarrhea to life-threatening colitis. Contact your healthcare provider if your diarrhea does not improve or worsens.
  • Talk to your healthcare provider before taking XIFAXAN if you have severe hepatic (liver) impairment as this may cause increased effects of the medicine.
  • Tell your healthcare provider if you are taking drugs called P-glycoprotein inhibitors (such as cyclosporine) because using these drugs with XIFAXAN may lead to an increase in the amount of XIFAXAN absorbed by your body.
  • If you are pregnant, planning to become pregnant, or nursing, talk to your healthcare provider before taking XIFAXAN because XIFAXAN may cause harm to an unborn baby or nursing infant.
  • In clinical studies, the most common side effects of XIFAXAN were:
    • HE: peripheral edema (swelling, usually in the ankles or lower limbs), nausea (feeling sick to your stomach), dizziness, fatigue (feeling tired), and ascites (a buildup of fluid in the abdomen).
    • IBS-D: Nausea (feeling sick to your stomach) and an increase in liver enzymes.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

For product information, adverse event reports, and product complaint reports, please contact:

Salix Product Information Call Center
Phone: 1-800-321-4576
Fax: 1-510-595-8183
Email: salixmc@dlss.com

Please click here for full Prescribing Information.